“It was actually indistinguishable from a healthy participant watching the movie,” says Adrian Owen, a neuroscientist at the University of Western Ontario in London, Canada (see: 'Neuroscience: The mind reader').
This shouldn't come as a surprise. Insulin doesn't merely signal the body's somatic cells to take up glucose; it also governs the brain's uptake of glucose. And glucose is what powers the brain. It's the brain's primary energy molecule.
We've known for some time that the brain itself makes a certain amount of insulin, and various parts of the brain are rich in insulin receptors.
Released as supporting evidence in a class-action suit against the league, the report calculated that the NFL's proposed settlement of $675 million will be sufficient to award damages to affected former players. Out of the 19,400 former league players, the NFL and opposition lawyers estimate that around 28 percent of them, about 6,000 individuals, will develop Alzheimer's disease or some other form of dementia as a consequence of their time playing for the NFL.
One of the key harms of the urine catheter is illustrated by a very instructive case vignette published in JAMA Internal Medicine as part of the wonderful Teachable Moments series. An 80 year old man with was admitted with fluid overload due to kidney disease. A urine catheter was placed to monitor his fluid status, and after several days he was discharged home in better condition.
Or so it seemed. Unfortunately, 5 days later he became seriously ill with an infection that started in his bladder (urinary tract infection) that then spread to his blood (sepsis). He required care in the intensive care unit. The value on his prior admission of precisely assessing how much urine he was producing was clearly not worth the risk of this disastrous and life threatening complication.
For patients who have suffered this type of stroke, surgical intervention can spell the difference between recovery or long-term disability and death, yet patients on Medicare are less likely than those with private insurance to be referred for surgical treatment, according to findings published in the journal PLOS ONE. This may represent a conscious or unconscious bias against Medicare patients, who are typically older and have preexisting disabilities or chronic illnesses, said Azra Bihorac, M.D., senior author of the study and an associate professor of anesthesiology, medicine and surgery at the UF College of Medicine.
"Not every hospital has skilled neurosurgeons who specialize in subarachnoid hemorrhage," Bihorac said. "If these hospitals don't have the necessary expertise, then they may actually overestimate the risk of a bad prognosis. They may assume that the patient won't do well anyway, so they won't proceed with surgery."
Mainly used to treat anxiety and insomnia, benzodiazepines are widely used in developed countries, particularly among the elderly. Because of strong withdrawal symptoms, and because long-term effectiveness of the benzodiazepines remains unproved, international guidelines recommend only short-term use of the drugs.
The study found that benzodiazepine use for 3 months or more was associated with an increased risk of Alzheimer's disease of up to 51%. The longer the exposure to benzodiazepines, the greater the risk of Alzheimer's. Long-acting benzodiazepines were also found to increase risk more than short-acting benzodiazepines.
The researchers report that adjusting for symptoms that might suggest dementia onset - such as anxiety, depression or sleep disorders - "did not meaningfully alter the results."
How can we meet the market demands for more care at home and ensure this critical workforce is respected and recognized for their contribution? The Eldercare Workforce Alliance, in a recently released brief, offers one proposal. While not a cure-all, the creation of an Advanced Direct Care Worker position – a rung in the career ladder above home health or personal care aides - may help to address the challenges we face in providing quality care to older adults across all settings.
The Institute of Medicine recommends clinicians minimize interventions in patients with life-limiting disease and instead focus on maximizing quality of life. Few studies have examined the use of chronic disease medications in patients with advanced dementia. Data also is lacking on the associated costs of such prescribing patterns.