Microglia are the brain's immune cells; so the idea is that they increase in numbers and trigger chronic inflammation....
“The general thought has been that these cells are supposed to be beneficial in the nervous system under normal conditions” said Long-Jun Wu, a professor of cell biology and neuroscience at Rutgers University. “But, in fact, in those with this neuropathic pain the cells, known as microglia, have proliferated and instead become toxic.”
In new research, published in both Nature Communications and Cell Reports, Wu and his team discovered that chronic neuropathic pain – caused by nerve damage as a result of an injury, surgery or a debilitating disease like diabetes or cancer – could be greatly reduced in animals if the injury was treated by targeting microglia within a few days.
“If we can catch that window within one to five days to inhibit microglia after nerve injury, we can partially reverse the development of chronic pain,” said Wu. “If we were able to deplete the microglia cells causing the condition before nerve injury occurs, we can permanently prevent it.”