http://goo.gl/2sKpcv
A decade of Alzheimer's disease research dominated by artificially creating symptoms in genetically modified mice has failed to find a single cure that works in human patients, and could be delaying progress towards effective treatments, says a new paper published in Drug Discovery Today.
The paper by Dr Gill Langley, senior science adviser to Humane Society International, calls for a fundamental paradigm shift in Alzheimer's disease research - utilising state-of-the-art techniques based on human rather than non-human biology. Next-generation tools such as functioning human brain cells in a test tube, neuroimaging and genomics must form the basis of a new framework for research that analyses the disease 'pathways' leading to Alzheimer's, from the cell and tissue level to the whole body scenario.