http://goo.gl/z1ECYH
Mast cells play a key role in the disease process in allergies: As a reaction towards an allergen - for example pollen or dust mites - they release big amounts of substances that initiate an inflammatory process. Study leader Hideaki Morita and his team discovered that mast cells are not only "bad guys", but also have a "good side" (see figure): They release the substance interleukin-2 that induces the production of certain immune cells called T-regulatory (Treg) cells. Treg cells can suppress the allergic inflammatory process in the airways induced by interleukin-10.
It is already known for some time that Treg cells can subdue an excessive immune response and the resultinginflammation. For example, injections with Treg cells prevented autoimmune diseases in mice. However, for Treg cell treatments one needs a large amount of these cells, which is not easy to realise. In the blood, there are just a few of them, and in vitro they are difficult to produce. Using mast cells, Treg cells could be easily produced in the laboratory in large quantities. "The mechanism that we discovered, could be the basis for a new way to handle allergies," says Hideaki Morita.