They found grade 1 level evidence in favour of a protective effect for the female hormone oestrogen,cholesterol lowering drugs (statins), drugs to lower high blood pressure, and anti-inflammatory drugs (NSAIDs).
They found the same level of evidence for folate, vitamins C and E, and coffee, all of which were associated with helping to stave off the disease.
Similarly, the pooled data indicated a strong association between high levels of homocysteine - an amino acid manufactured in the body - and depression and a significantly heightened risk of developing Alzheimer's disease.
The evidence also strongly pointed to the complex roles of pre-existing conditions as either heightening or lowering the risk.
The factors associated with a heightened risk included frailty, carotid artery narrowing, high and low blood pressure, and type 2 diabetes (in the Asian population). Those associated with a lowered risk included a history of arthritis, heart disease, metabolic syndrome, and cancer.
“Patients regularly face long waiting times for scans due to a lack of MRI systems and in the developing world there are many countries that do not have a single MRI unit or have only very old systems in large cities. For a person with a serious injury or illness, it’s not possible to travel hundreds of kilometres to get a diagnosis, let alone be able to afford it.”
A major contributor to the cost of MRI systems is constant cooling of a key part of the system - the magnet - to remain within a set temperature range. To achieve this, the magnet is immersed in a helium ‘bath’. Helium is very expensive and there are concerns about global supply shortages,” Dipak said.
“If a helium-cooled MRI unit has a power outage, the helium boils off, or evaporates, as the magnet heats up. It’s very expensive to refill the cooling chamber and this leads to lengthy downtime during which the system cannot be operated.”
To get around the helium issue, researchers at ISEM, led by ARC Future Fellow Associate Professor Jung Ho Kim, have developed a prototype for a new magnet and cooling system that will enable them to build a low-cost and easy-to-operate MRI system.
Long overview of research. This thread of biological research is part of a general recent scientific trend that shows the astounding complexity of life....
Hundreds of trillions of microbes live in the human gut, with 300 times the total DNA as humans. The products of this “forgotten organ” include large amounts of DNA that are critical to create necessary human nutrients, for essential metabolism and to develop the most effective immune system. Recent research shows dramatic effects of microbe products from the gut on mental function—depression, stress, autism, and degenerative illness. In humans, many studies show microbes affect anxiety, mood, depression and social behavior. Direct effects are through secreted products, stimulation of the enteric nervous system and travel of microbes into the brain, while indirect factors are microbes’ influence on immune function affecting behavior. Microbes produce molecules that transform into hormones and neurotransmitters or they produce neurotransmitters themselves. Microbes effect on the brain includes fetal development and neurotransmitter function.
In most people, the master body clock runs slightly longer than 24 hours. What this means is that rather than cycle on a 24-hour day, most people's natural rhythms actually cycle a bit longer. Whether the cycle runs two minutes or 30 minutes longer, if you have Non-24 these minutes add up day after day, a few one day adding to a few more the next, eventually causing a noticeable change in the times during the day when your body expects to sleep and expects to be awake.
Though Non-24 may appear to be a sleep disorder, it isn't. It's actually a serious, chronic circadian rhythm disorder very common in people who are totally blind, and it can arise at any age. Currently, there are 1.3 million people who are legally blind in the United States. Of the legally blind, 130,000 have no light perception (i.e., totally blind), and as many as 70% suffer from Non-24.