Sounds too technical to be useful, but is important. Organophosphate insecticides are the weaker children of nerve agents like Sarin (allegedly used by Syria recently) and VX, as well as a host of others. Malathion is probably the best known of the recent organophosphates. The justification for use of modern organophosphates is that they breakdown; Malathion is supposed to be gone in 30 days. This paper says that gut microbes are part of the process of breaking down organophosphates and this breakdown alters the gut microbes so that the individual becomes glucose intolerant and develops one or another of diabetic conditions. This is important to me because I had high exposure to Malathion in Vietnam. Malathion remains the most commonly used organophosphate for mosquito control in municipalities.......
Here we demonstrate a high prevalence of diabetes among people directly exposed to organophosphates in rural India (n = 3080). Correlation and linear regression analysis reveal a strong association between plasma organophosphate residues and HbA1c but no association with acetylcholine esterase was noticed. Chronic treatment of mice with organophosphate for 180 days confirms the induction of glucose intolerance with no significant change in acetylcholine esterase.
Collectively, our results implicate gluconeogenesis as the key mechanism behind organophosphate-induced hyperglycemia, mediated by the organophosphate-degrading potential of gut microbiota. This study reveals the gut microbiome-mediated diabetogenic nature of organophosphates and hence that the usage of these insecticides should be reconsidered.